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Abstracts |

Some Direct Hepatic and Metabolic Effects of Alcohol.

Charles S. Lieber, M.D.; and Charles S. Davidson, M.D.
Ann Intern Med. 1964;60(4):720. doi:10.7326/0003-4819-60-4-720_1
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Various recent studies have demonstrated that some pathologic changes observed on excessive alcohol intake may result not only from nutritional deficiencies but also from direct metabolic effects of alcohol. Both in man and in rats, alcohol produced fatty livers, despite adequate dietary intake. In rats, this alcoholic fatty liver could not be prevented by methionine supplements. Isocaloric replacement of the alcohol by carbohydrate or fat (resulting in the administration of a high fat diet) did not produce fatty livers. During the initial stages of fatty liver development, serum cholesterol, phospholipids, and especially triglycerides increased. This suggests, in contrast with other




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