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Abstracts |

B-Complex Vitamins in Liver Disease.

Carroll M. Leevy, M.D., F.A.C.P.; Herman Baker, Ph.D.; Willem tenHove, M.D.; Oscar Frank, Ph.D.; and Gilbert R. Cherrick, M.D.
Ann Intern Med. 1964;60(4):721. doi:10.7326/0003-4819-60-4-721_1
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Supplemental B-complex vitamins are widely given in liver disease, however, the usefulness of such therapy in improving hepatic status is not known. The present paper records observations on the influence of liver injury on B-complex vitamin utilization, and effects of B-complex deficiency on perpetuation of hepatic disease. Studies were conducted in experimental animals and man to determine (a) the influence of necrosis, teatosis, and cirrhosis of the liver on hepatic uptake storage, and utilization of B-complex vitamins, and (b) the effect of B-complex vitamin deficiency on hepatic subcellular structure and regenerative potential. Circulating and tissue vitamin levels were measured microbiologically;


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