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Chromatographic Separation of Pepsinogens and Pepsins from Human Gastric Mucosa and Urine.

Harry L. Segal, M.D., F.A.C.P.; Michael D. Turner, M.D.; Leon L. Miller, M.D.; and Max J. Seijffers, M.D.
Ann Intern Med. 1964;60(4):721. doi:10.7326/0003-4819-60-4-721_2
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By the application of column chromatography with the use of a cellulose ion exchange resin the authors have observed the separation of three different pepsinogens (designated as pepsinogen I, II and III) from gastric mucosa, three pepsins from gastric juice and two pepsinogens (pepsinogen II and III) from the urine of the same patient.

Chromatography of the acidified gastric mucosa revealed a peak not seen during chromatography of the acid juice secreted by the same gastric mucosa. This resulted in a study which demonstrated that each human pepsinogen formed after acidification and subsequent neutralization a compound which in its behavior


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