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Current Concepts of the Pathogenesis of the Ethanol Induced Fatty Liver.

Robert Scheig, M.D.; and Kurt J. Isselbacher, M.D.
Ann Intern Med. 1964;60(4):721-722. doi:10.7326/0003-4819-60-4-721_3
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Ethanol administration leads to an accumulation of triglyceride in the liver. The additional fatty acid incorporated in this triglyceride could be derived from the peripheral depots by increased mobilization, or from the liver itself as a consequence of increased synthesis or decreased oxidation. We have found that the in vivo and in vitro effects of ethanol on fatty acid metabolism differ. Thus, while the in vitro effects of ethanol are increased synthesis and decreased oxidation of fatty acids in the liver, its in vivo effects are enhanced mobilization of fatty acids from peripheral depots and increased incorporation of circulating free



ethanol ; fatty liver

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