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Abstracts |

The Gastrointestinal Lesion in Viral Hepatitis.

Maj. Marcel E. Conrad; Roberta S. Hartman, Ph.D.; and Giovanni Astaldi, M.D.
Ann Intern Med. 1964;60(4):723. doi:10.7326/0003-4819-60-4-723_2
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Twenty-five servicemen hospitalized in Korea with infectious hepatitis underwent repeated biopsy of the small intestine. Each volunteer was jaundiced and had clinical, laboratory, and liver biopsy evidence of viral hepatitis. Intestinal biopsies were obtained with Crosby intraluminal biopsy capsules and the specimens were prepared for both light and electron microscopy. During the early icteric stage of hepatitis, duodenal and jejunal biopsies showed shortened and club-shaped villi. There were increased numbers of goblet cells lining the mucosa with round-cell infiltration of the submucosa. When the illness was severe with a prolonged clinical course the mucosal surface was flattened with almost complete


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