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Neonatal Unconjugated Hyperbilirubinemia Associated with Breast-feeding and a Steroid in Milk That Inhibits Glucuronide Formation in Vitro.

Irwin M. Arias, M.D.; Mathilda Furman; Lawrence M. Gartner, Ph.D.; and Sam Seifter, Ph.D.
Ann Intern Med. 1964;60(4):724. doi:10.7326/0003-4819-60-4-724_2
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Six unrelated 2-week-old breast-fed infants who were clinically well had serum unconjugated bilirubin concentrations of 15.0 to 24.3 mg/100 ml not due to known causes. The hyperbilirubinemia disappeared within 5 days after cessation of breast-feeding in five infants. The sixth infant alternated breast and artificial feeding and became anicteric 12 days later at 4 weeks of age. The mothers had breast-fed five previous children, four of whom had unexplained and prolonged jaundice. Breast milk obtained from these women strongly inhibited the formation of O-aminophenol glucuronide and direct-reacting bilirubin by rat, guinea pig, and rabbit liver homogenates and microsomes in vitro.

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