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Abstracts |

Response of Malabsorption of Tropical Sprue to Antibiotics.

Ricardo Guerra, M.D.; Maj. Munsey S. Wheby; Maj. Barbara Baggs; and Capt. Theodore M. Bayless
Ann Intern Med. 1964;60(4):725. doi:10.7326/0003-4819-60-4-725_1
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Patients with tropical sprue treated with folic acid or vitamin B12 usually show general improvement, although frequently, malabsorption persists. Altered bacterial flora has been implicated in other malabsorption states. Somewhat conflicting evidence has been reported regarding the effect of antibiotics in tropical sprue. The efficacy of long-term antibiotic therapy in alleviating malabsorption was evaluated in ten patients with persistent symptoms and malabsorption despite treatment with folic acid, vitamin B12 and gluten free diet (Group I), and in eight untreated patients with sprue (Group II). After baseline hematologic and absorptive studies including fecal fat excretion, D-xylose excretion, serum carotene, and jejunal


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