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Abstracts |

Secretion of Pancreatic Enzymes in Response to Secretin and Pancreozymin.

Leslie Zieve, M.D., F.A.C.P.; Stephen Silvis, M.D.; and William Blackwood, M.D.
Ann Intern Med. 1964;60(4):725. doi:10.7326/0003-4819-60-4-725_2
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The secretion of pancreatic enzymes by normal and abnormal subjects was evaluated utilizing a standardized procedure in which secretin (SN) and pancreozymin (PZ) were injected intravenously simultaneously, and duodenal aspirations made for ½ hr immediately before and after the injection. In addition to the volume, pH, and bicarbonate content of the fluid aspirated, the following enzymes were measured: amylase, lipase, phospholipase A, trypsin, chymotrypsin, carboxypeptidase, leucine aminopeptidase, and desoxyribonuclease. All but the last two proved useful in the evaluation of pancreatic function. After an overnight fast, the median resting and post SN + PZ enzyme content in 12 normal subjects


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