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Iron Loading Anemia: Treatment with Pyridoxine and Repeated Phlebotomies.

Capt. Lewis R. Weintraub; Maj. Marcel E. Conrad; and Col. William H. Crosby
Ann Intern Med. 1964;60(4):728. doi:10.7326/0003-4819-60-4-728_2
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Iron-loading anemias are characterized by: (1) hypochromic microcytic red cells, (2) elevated serum iron with saturated TIBC, (3) siderosis of body tissues, and (4) sideroblasts in the bone marrow and circulating siderocytes. Two cases are presented which demonstrated a partial hematologic response after pyridoxine therapy. Iron59 studies revealed increased intestinal absorption and poor red cell utilization of iron before and after therapy. These findings explained the excessive siderosis of the liver and bone marrow which was seen in biopsy material from both cases. Energetic phlebotomy therapy was then instituted. Approximately 7 g of iron were removed from one patient during


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