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Observations on the Gastrointestinal Administration of Bovine Splenic Homogenate on Hematopoiesis in Man.

Raymond W. Monto, M.D., F.A.C.P.; James A. Barron, M.D.; John W. Rebuck, M.D.; and Vainutis Vaitkevicius, M.D., F.A.C.P.
Ann Intern Med. 1964;60(4):729. doi:10.7326/0003-4819-60-4-729_1
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Thirty-two patients with a variety of refractory hematologic cytopenic disorders received bovine splenic (27), renal (2), muscle (1), thymus homogenate (1), and blood (1) by continuous intragastric tube feeding. Fresh and frozen whole homogenate, supernatant and sediment were given in amounts of approximately 1,000 g daily for 7 to 14 days. Rats received whole splenic homogenate, supernatant, and sediment in the quantity of 10 g spleen or 24 ml supernatant daily by gastric tube for 5 days.

In patients, the following determinations were made at 2-day intervals: hemoglobin, hematocrit, red cell, reticulocyte and platelet counts, and serum uric acid. Bone


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