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Abstracts |

The Antagonistic Actions of Antigen Producing Immunity and Immunological Tolerance.

David W. Talmage, M.D.
Ann Intern Med. 1964;60(4):730. doi:10.7326/0003-4819-60-4-730_2
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A molecular model of antibody production is presented which is based solely on selective induction. According to this model the potential to make the various antibodies is distributed randomly among immature lymphoid cells, each cell being precommitted to a limited number of antibodies. The reaction of antigen with these immature cells has two separate and antagonistic actions mediated through two separate molecular bridges between antigen and deoxyribonucleic acid. A specific stimulus occurs after a reaction of antigen with strategically located preformed antibody and results in the passage of messenger ribonucleic acid from the nucleus into the cytoplasm. The net effect


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