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Abstracts |

The Immunology of Transplantation.

Rupert E. Billingham, Ph.D.
Ann Intern Med. 1964;60(4):733. doi:10.7326/0003-4819-60-4-733_2
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An introductory account of the basic principles of transplantation immunology will be briefly presented. This will include a survey of the various manifestations of homograft-type reactivities, and of the genetic determination and chemical nature of the isoantigenic determinant groups responsible for eliciting the homograft reaction.

The widely held thesis, that the reaction evoked by solid tissue homografts that establish vascular connections with their hosts is put into effect by blood-borne, immunologically activated cells of the lymphocytic series, will be critically discussed in the light of recent work. Pertinent evidence derives from studies: (1) on the adoptive transfer of sensitivity to


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