The full content of Annals is available to subscribers

Subscribe/Learn More  >
Abstracts |

Factors Controlling the Release of Endogenous Pyrogen from Polymorphonuclear Leukocytes.

W. Barry Wood Jr., M.D., F.A.C.P.
Ann Intern Med. 1964;60(4):732. doi:10.7326/0003-4819-60-4-732_2
Text Size: A A A
This excerpt has been provided in the absence of an abstract.

The role of endogenous pyrogen in the pathogenesis of fever will have been discussed by the preceding speaker. That polymorphonuclear leukocytes constitute a major source of the endogenous pyrogen is clearly established. The mechanisms responsible for its release from leukocytes, on the other hand, are only partially understood.

Evidence will be presented that the release of pyrogen from granulocytes occurs in vivo: (a) when the cells engage in phagocytosis, (b) when they are exposed to appropriate concentrations of bacterial endotoxin, and (c) when they leave the blood stream and enter tissue exudate fluid, where they are acted upon by a



neutrophil ; pyrogens

First Page Preview

View Large
First page PDF preview





Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Submit a Comment/Letter
Submit a Comment/Letter

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.


Buy Now for $42.00

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Related Articles
Journal Club
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.