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Abstracts |

Immunological Deficiency States.

Charles A. Janeway, M.D.
Ann Intern Med. 1964;60(4):733. doi:10.7326/0003-4819-60-4-733_1
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For years, clinicians were primarily concerned with states of immunological hyperactivity, but in recent years attention has been turned to an ever-broadening spectrum of clinical conditions in which hypofunction of the immunologic apparatus of the body either occurs spontaneously or is produced purposefully in order to restrain the manifestations of hypersensitivity or to prevent homograft rejection.

Combined evidence from clinical observations on patients and experimental work in animals makes it apparent that the capacity to manifest the delayed type of hypersensitivity and the ability to form antibodies are both dependent upon the integrity of the lymphoid structures, and that the


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