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Correlative Clinicopathological Studies of Patients Following Acute Renal Failure.

Robert C. Muehrcke, M.D., F.A.C.P.; Robert M. Kark, M.D., F.A.C.P.; Conrad L. Pirani, M.D., F.A.C.P.; and Seymour Rosen, M.D.
Ann Intern Med. 1964;60(4):736. doi:10.7326/0003-4819-60-4-736_2
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Correlative clinicopathological studies were made of renal biopsies from five patients with acute oliguric renal failure resulting from apparent tubular necrosis. The acute tubular necrosis followed shock in three patients, CCL4 poisoning in one, and arsine toxicity in one. In four patients, renal biopsies were done after the patients made a recovery from acute renal failure. Serial renal biopsies were performed on one patient with arsine toxicity during each of the following periods: (1) complete anuria, (2) early diuretic phase, (3) height of diuresis, and (4) 6 months after recovery from acute renal failure. These serial biopsies were studied by


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