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Abstracts |

Renal Tubular Acidosis Secondary to Degraded Tetracycline.

John M. Weller, M.D., F.A.C.P.; and Laurence Wegienka, M.D.
Ann Intern Med. 1964;60(4):738. doi:10.7326/0003-4819-60-4-738_1
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A 39-year old female acutely developed severe acidosis following ingestion of outdated tetracycline. Studies with the ammonium chloride loading test done 2 months after the acute episode showed a persistent renal tubular defect in hydrogen ion excretion. This tubular disorder appeared to be a primary deficiency in renal tubular cell hyrogen ion production or transport, or both. There was no evidence for defective renal tubular bicarbonate re-absorption, inadequate ammonia formation or insufficiency of phosphate ion excretion to act as a hydrogen ion acceptor. Re-valuation 1½ yr later, also with ammonium chloride loading, showed that renal tubular hydrogen ion excretion had


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