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Studies of Mechanism of Action and Effectiveness of Ethacrynic Acid, A New and Unique Diuretic Agent.

Paul J. Cannon, M.D.; and John H. Laragh, M.D.
Ann Intern Med. 1964;60(4):738-739. doi:10.7326/0003-4819-60-4-738_3
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Ethacrynic acid has been found to be a most potent natriuretic and diuretic agent in man. The compound is an unsaturated ketone derivative of phenoxyacetic acid, chemically entirely different from previously known diuretic agents. The present study of over 50 patients suggests that its mode of action is also unique.

Oral dosages of 100 to 200 mg per day produced marked increases in sodium chloride and water excretion and clearing of edema fluid in refractory patients with congestive heart failure or with cirrhosis and ascites. It was often effective when all other measures had failed. Its diuretic effects were additive


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