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Antibody Deficiency Syndrome Associated with Dysgammaglobulinemia.

Werner F. Barth, M.D.; Thomas J. Liddy, M.D.; Yasukazu Tanaka, M.D.; Richard A. Malmgran, M.D.; and John L. Fahey
Ann Intern Med. 1964;60(4):739. doi:10.7326/0003-4819-60-4-739_2
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The association of the antibody deficiency syndrome with agammaglobulinemia is well known. Similar immune deficiency syndromes characterized by repeated infections and a poor response to antigenic challenge also may occur in patients with selective deficiencies of the immunoglobulins, that is, dysgammaglobulinemia. Investigation of these cases has helped to shed light on human genetics, immunoglobulin production, and antibody formation.

Observations in a 15-year-old Navajo Indian female with marked reduction of the β2A and 6.6S gamma globulins associated with elevated γ1-macroglobulin levels will be reported. This child has had repeated infections since 2 years of age characterized by recurrent pneumonia, sinusitis, and


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