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A Prospective Study of Peptic Ulcer in Patients with Rheumatoid Arthritis.

E. S. Mongan, M.D.; E. C. Atwater, M.D.; R. F. Jacox, M.D.; and D. R. Wieche, M.D.
Ann Intern Med. 1964;60(4):740. doi:10.7326/0003-4819-60-4-740_1
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There are conflicting reports in the literature regarding the relationship of peptic ulcer to rheumatoid arthritis and corticosteroid therapy. This report deals with a prospective study of this problem. Forty-three patients with rheumatoid arthritis were classified with respect to their clinical status, before and at the time of the study. All had definite rheumatoid arthritis (according to the revised criteria of the American Rheumatism Association) and all had demonstrable rheumatoid factor in the serum.

Two groups of patients were compared. The first group consisted of 25 patients with class III or IV (Steinbrocker) rheumatoid arthritis who had never taken corticosteroids


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