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Benzidine-positive Pigments in Serum of Patients with Sickle Cell Anemia During Painful Crises

Ann Intern Med. 1964;60(6):1022-1027. doi:10.7326/0003-4819-60-6-1022
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Previous studies have shown that there is no evidence of a significant increase in the rate of hemolysis of red cells in patients with sickle cell anemia at the time of their painful crisis as compared with the steady state and as revealed by erythrocyte values, reticulocytes and nucleated red cells in circulating blood, and by bile pigments in plasma, urine, and feces (1). Further evidence supporting the thesis that hemolysis is not a major component in the recurrent episodes of pain and fever is furnished by studies of the concentration of benzidine-positive pigments in the plasma. It is the


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