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Familial Pheochromocytoma and Thyroid Carcinoma

Ann Intern Med. 1964;60(6):1028-1040. doi:10.7326/0003-4819-60-6-1028
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Pheochromocytoma is a catecholamine-secreting tumor arising either from the adrenal medulla or from chromaffin tissue located elsewhere in the body. A familial occurrence has been demonstrated, with sixteen affected kindred thus far reported (1-15). An association with thyroid carcinoma has also been shown (12, 16, 17) and two recent publications (14, 18) have reported the thyroid carcinoma to be a newly described (19) medullary (solid) carcinoma with amyloid infiltration.

This report will describe the occurrence of bilateral pheochromocytoma and of thyroid carcinoma in a mother and her daughter. The mother died after attempted adrenalectomy 25 years ago. The daughter recently


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