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Marrow Iron: An Evaluation of Depleted Stores in a Series of 1,332 Needle Biopsies

L. D. ELLIS, M.D.; W. N. JENSEN, M.D., F.A.C.P.; and M. P. WESTERMAN, M.D.
Ann Intern Med. 1964;61(1):44-49. doi:10.7326/0003-4819-61-1-44
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Examination of the bone marrow for stainable iron has been considered to be "the most valuable clinical procedure for determining adequacy of body iron stores" (1). Increased concentrations have been observed in patients with pernicious anemia, hemolytic anemias, marrow aplasia, uremia, chronic infection, hemochromatosis, and hemosiderosis (2). Decreased or absent marrow iron stores have been consistently reported in patients with iron deficiency anemia (2-7), observed in "tired young women" (3), and described in association with rheumatoid arthritis (8,9). The absence of marrow iron stores is generally accepted as the "sine qua non of iron deficiency" (10). Previous studies of marrow

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iron ; biopsy, needle

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