0

The full content of Annals is available to subscribers

Subscribe/Learn More  >
Case Reports |

Hypofibrinogenemic Hemorrhage in Acute Myelogenous Leukemia Treated with Heparin: With Autopsy Findings of Widespread Intravascular Clotting

WILLIAM G. BAKER, M.D.; NILS U. BANG, M.D.; RALPH L. NACHMAN, M.D.; FARRO RAAFAT, M.D.; and HERBERT I. HOROWITZ, M.D.
Ann Intern Med. 1964;61(1):116-123. doi:10.7326/0003-4819-61-1-116
Text Size: A A A
This excerpt has been provided in the absence of an abstract.

Hemorrhage is a frequent complication of acute leukemia. A recent review of acute leukemia presented evidence of bleeding in 66% of 322 cases and showed that it was the principal cause of death in 44% (1). The pathogenesis of hemorrhage in most cases of acute leukemia is quite obvious: leukemic replacement of normal bone marrow results in severe thrombocytopenia (2, 3). Occasionally, the cause is more obscure, being variously ascribed to qualitative platelet deficiencies (4), vascular endothelial damage from anoxia or lysins (5), leukemic infiltration of vessel walls (6), or circulating anticoagulants (7, 8). Recent studies report that in certain

...

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Letters

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Comments

Submit a Comment
Submit a Comment

Summary for Patients

Clinical Slide Sets

Terms of Use

The In the Clinic® slide sets are owned and copyrighted by the American College of Physicians (ACP). All text, graphics, trademarks, and other intellectual property incorporated into the slide sets remain the sole and exclusive property of the ACP. The slide sets may be used only by the person who downloads or purchases them and only for the purpose of presenting them during not-for-profit educational activities. Users may incorporate the entire slide set or selected individual slides into their own teaching presentations but may not alter the content of the slides in any way or remove the ACP copyright notice. Users may make print copies for use as hand-outs for the audience the user is personally addressing but may not otherwise reproduce or distribute the slides by any means or media, including but not limited to sending them as e-mail attachments, posting them on Internet or Intranet sites, publishing them in meeting proceedings, or making them available for sale or distribution in any unauthorized form, without the express written permission of the ACP. Unauthorized use of the In the Clinic slide sets will constitute copyright infringement.

Toolkit

Buy Now

to gain full access to the content and tools.

Want to Subscribe?

Learn more about subscription options

Advertisement
Related Articles
Related Point of Care
Topic Collections
PubMed Articles
Forgot your password?
Enter your username and email address. We'll send you a reminder to the email address on record.
(Required)
(Required)