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Chronic Medical Therapy for Pheochromocytoma: A Report of Four Cases

Ann Intern Med. 1964;61(2):229-241. doi:10.7326/0003-4819-61-2-229
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Since the first successful operation for pheochromocytoma in 1927 (1), the treatment of choice for this condition has been surgical excision of the tumor. Pharmacological therapy with phentolamine methanesulfonate (Regitine®, Ciba Pharmaceutical Products) or phenoxybenzamine (Dibenzyline®, Smith, Kline & French) to prepare the patient with a pheochromocytoma for surgery and the use of phentolamine to control the paroxysmal hypertensive crises encountered during surgery have gained wide acceptance. However, the use of these adrenolytic drugs in the chronic treatment of patients with resectable pheochromocytoma or with medical contra-indications to surgery has not been widely reported. The results of chronic therapy with


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