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Nonbeta Islet-cell Carcinoma of the Pancreas Presenting as Diarrhea: Report of a Case

Ann Intern Med. 1964;61(3):539-543. doi:10.7326/0003-4819-61-3-539
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The association of severe peptic ulcer disease with a noninsulin-producing islet-cell carcinoma of the pancreas was described by Zollinger and Ellison (1) in 1955, and by 1960 more than 80 cases of this syndrome had been reported (2). It is now recognized that in this syndrome the initial symptom may be severe diarrhea, preceding peptic ulcer formation by many months or years (2-8). The case reported here is an example of a nonbeta islet-cell carcinoma initially presenting as a severe diarrhea.

REPORT OF A CASE: A 16-year-old Negro boy was first examined at the Cleveland Clinic Hospital in January, 1961.


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