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Antibiotic Therapy in Tropical Sprue: The Role of Dietary Folic Acid in the Hematologic Remission Associated with Oral Antibiotic Therapy

Ann Intern Med. 1964;61(4):721-728. doi:10.7326/0003-4819-61-4-721
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The initial observations made 20 years ago that treatment with sulfonamide preparations arrested the diarrhea of military personnel in India afflicted with tropical sprue (1-3) have subsequently been confirmed and amplified. Anderson and co-workers (4) and French, Gaddie, and Smith (5) observed a gastrointestinal remission in all of seven British soldiers who had acquired tropical sprue in the Far East and were treated with broad spectrum antibiotics in Birmingham, England. Subsequently, studies of Puerto Rican patients, both in Puerto Rico (6, 7) and in New York City (8), and of Indian subjects in London (9, 10) have confirmed the fact


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