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Antinuclear Factors in Rheumatoid Arthritis and Lupus Erythematosus.

Eugene V. Barnett, M.D.; John J. Condemi, M.D.; Ralph Jacox, M.D., F.A.C.P.; and John H. Vaughan, M.D., F.A.C.P.
Ann Intern Med. 1964;61(4):796-797. doi:10.7326/0003-4819-61-4-796_3
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Antinuclear factors (ANF) have been found in the sera of adults and children with lupus erythematosus (LE) and in a proportion of adults and children with rheumatoid arthritis (RA). This study describes the incidence with which ANF occurs in the three major classes of immunoglobulins, γ2 γ1A, and γ1M globulins in these groups of patients. These findings are correlated with the incidence of rheumatoid factor and the duration and severity of disease.

Positive tests for ANF were obtained in 18 of 20 adults with LE, 36 of 132 adults with RA, 8 of 22 children with RA, and 4% of


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