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Mitral Valve Regurgitation Caused by Infarcted Papillary Muscles: A Report of Fifteen Cases.

Michael D. Orlando, M.D.; Charles F. Wooley, M.D.; Dante Scarpelli, M.D.; and Joseph M. Ryan, M.D.
Ann Intern Med. 1964;61(4):801. doi:10.7326/0003-4819-61-4-801_1
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The frequency of papillary muscle infarction, without rupture, producing mitral regurgitation is not generally appreciated. We studied ten males and five females, ages 35 to 81. There was a history of definite infarction in 11 patients, probable infarction in 4. An apical systolic murmur was present in all 15, pansystolic in 10. Electrocardiographic evidence of infarction was definite in 12 instances (with posterior involvement in 10), and suggestive in 3. Seven patients are alive, 1 to 7 years following infarction (four have developed congestive failure). Eight patients have expired 1 to 10 years following infarction, with autopsy correlation in all.


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