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The Output of Pancreatic Protein after Pancreozymin: A Test of Pancreatic Exocrine Function.

Donald H. Hanscom, M.D.; James V. Dunphy, M.D.; and Armand Littman, M.D., Ph.D., F.A.C.P.
Ann Intern Med. 1964;61(4):804-805. doi:10.7326/0003-4819-61-4-804_4
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Our previous dose-response data on pancreozymin (PZ) in humans indicated progressively better discrimination between normal and pancreatic patients with increasing doses of PZ. With the new Jorpes-Mutt preparation of PZ it is possible to give still larger doses. A clinical test was developed measuring the protein (enzyme) output from the pancreas in response to intravenously injected PZ (Cecekin, Vitrum, Stockholm). A double lumen Dreiling tube collected gastric and duodenal contents separately. A secretin test was done by inecting 1.5 µ/kg of secretin and collecting six 10-min samples. Then secretin was given by continuous intravenous infusion at a rate of 1.5


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