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Thrombotic Thrombocytopenic Purpura: Report of 16 Cases.

Edward L. Amorosi, M.D.; and John E. Ultmann, M.D., F.A.C.P.
Ann Intern Med. 1964;61(4):806. doi:10.7326/0003-4819-61-4-806_2
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Since 1925, 230 cases of thrombotic thrombocytopenic purpura (TTP) have been reported. This paper reports 16 cases of TTP, 11 females and 5 males, ages 16 to 60. Three patients were pregnant; one had recently aborted. Thrombocytopenic purpura was seen in 12 cases; however, severe hemorrhage was seen in only one. One patient had a normal platelet count. Hemolytic anemia with reticulocytosis (6 to 42%) was present in all but three patients. The Coombs test was negative in ten, tested. The LE-preparation was negative in six, examined. In 15 cases, headache, confusion, visual disturbances, aphasia, hemiparesis, seizures, or coma were


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