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Pseudomonas Endocarditis: A Therapeutic Challenge.

Robert S. Pressman, M.D., F.A.C.P.; Vladir Maranhao, M.D.; and Harry Goldberg, M.D., F.A.C.P.
Ann Intern Med. 1964;61(4):809-810. doi:10.7326/0003-4819-61-4-809_3
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Pseudomonas aeruginosa, a gram-negative organism, was considered virtually nonpathogenic prior to the antimicrobial era. However, its importance as a pathogen has been underestimated. When infections due to this organism occur, they are chiefly seen in the elderly and debilitated. Infection usually occurs after instrumentation, most frequently of the genito-urinary tract. Other parts of the world have had epidemics involving this organism. In addition, there are papers on generalized septicemias and highly fatal infections of the lungs, meninges and brain.

Review of the world literature revealed Pseudomonas endocarditis to be comparatively rare until the past decade. In 1953, there were five


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