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Abstracts |

The Effect of Diuretics on Plasma Volume and Renal Function in Patients with Ascites.

Fred L. Lieberman, M.D.
Ann Intern Med. 1964;61(4):815. doi:10.7326/0003-4819-61-4-815_1
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Diuretics are though to act by diminishing the plasma volume, thereby promoting the movement of ascites and edema fluid into the plasma to maintain equilibrium. Since renal function is dependent on renal blood flow, reduction in plasma volume during diuresis might compromise renal function. To determine if renal failure is a consequence of diuresis in cirrhosis, the plasma volume and endogenous creatinine clearance were measured before and after a large diuresis in 40 patients with alcoholic cirrhosis and ascites. The plasma volume was measured with radioactive serum albumin, and diuresis was induced by hydrochlorothiazide, ethacrynic acid, and spironolactone. Only 2


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