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Protein-losing Enteropathy Complicating Prolonged Bleeding in Hemophilia

Ann Intern Med. 1964;61(5_Part_1):928-932. doi:10.7326/0003-4819-61-5-928
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Gastrointestinal bleeding is a dangerous and frequently fatal complication of hemophilia. In the series of Wilkinson, Nour-Eldin, Israels, and Barrett (1) there were 67 incidences of gastrointestinal (G.I.) bleeding in 229 patients requiring an average of 8.6 units of blood per incident. Hemorrhage from the alimentary tract ranked equally with intracranial bleeding as the major cause of death in these patients. Recently, emphasis has been placed on the use of Factor VIII concentrates in the control of this disease (2-6). In the present case, this approach was not satisfactory, and therapeutic efforts directed against a superimposed enteropathy coincided with the


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