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Neonatal Tetany: Diagnostic Lead to Hyperparathyroidism in the Mother

Ann Intern Med. 1964;61(6):1109-1115. doi:10.7326/0003-4819-61-6-1109
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Since Von Recklinghausen's description of generalized osteitis fibrosa cystica, the clinical manifestations of hyperparathyroidism have undergone an apparent change. After early recognition of the renal complications of the disease (1), a variety of other manifestations of primary hyperparathyroidism were noted, including peptic ulcer (2), pancreatitis (3), multiple endocrine adenomata (4), pitressin resistant diabetes insipidus (5), and various psychologic manifestations (6). Patients with a classical picture of bone or renal disease have gradually become less common, whereas patients without these characteristic findings have been diagnosed more frequently (7). Indeed, in some the diagnosis has been arrived at only by serendipity (8).


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