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Nephrogenic Diabetes Insipidus Due to Sarcoidosis Without Hypercalcemia

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MAJOR, USA (MC)Heidelberg,Germany

Ann Intern Med. 1965;62(1):113-120. doi:10.7326/0003-4819-62-1-113
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Polyuria and polydipsia occurring in sarcoidosis has been previously described as the result of two entirely different pathogenetic mechanisms: [1] the production of primary or vasopressin-sensitive diabetes insipidus by discrete sarcoid lesions in the hypothalamic region, and [2] the occurrence of polyuria with renal failure and specific tubular lesions that prevent the concentration of urine, due to hypercalcemia and unresponsive to vasopressin.

The purpose of this case presentation is to record the occurrence of diabetes insipidus not due to these previously reported mechanisms in a patient in whom the diagnosis of generalized sarcoidosis was established by typical X-ray findings, biopsies


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