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Influence of Dietary Sodium on Renal Function in Patients with Chronic Renal Disease

Ann Intern Med. 1965;62(2):231-245. doi:10.7326/0003-4819-62-2-231
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In describing the life-threatening syndrome of renal salt-wasting, Thorn, Koepf, and Clinton (1) and others (2, 3) stated that the condition is not due to a single typical pathologic lesion in the kidney. Rather, they said, it may occur in the course of any insidious but progressive renal disease. In fact, the clinical picture and laboratory finding of hyponatremia may be the first indication of previously unrecognized disease of the kidneys (2).

Previous studies relating to the ability of patients with renal disease to conserve salt have yielded conflicting and inconclusive results. Cope (4) found that changes in dietary salt


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