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Editorials |

Allopurinol in the Treatment of Gout

JAMES B. WYNGAARDEN, M.D.; R. WAYNE RUNDLES, M.D.; and EARL N. METZ, M.D.
Ann Intern Med. 1965;62(4):842-847. doi:10.7326/0003-4819-62-4-842
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Elsewhere in this journal appear four papers on various aspects of gout. One by Malawista and Seegmiller represents a further study on the role of crystals of sodium urate in the pathogenesis of the acute attack, and of the effect of colchicine upon the inflammatory process. A second paper by Kaplan, Bernstein, Wallace, and Halberstam reports the presence of hyperamino-acidemia in hyperuricemic subjects and raises some questions concerning the fundamental metabolic disturbance of primary gout. A third paper by Gonick, Rubini, Gleason, and Sommers adds to our knowledge and mystery about the nature of the renal complications of gout. A

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gout ; allopurinol

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