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Peripheral Vascular Syndromes Associated with Systemic Lupus Erythematosus

Ann Intern Med. 1965;62(5):907-919. doi:10.7326/0003-4819-62-5-907
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Since the classic paper of Baehr, Klemperer, and Schifrin (1), systemic lupus erythematosus (SLE) has been recognized as a diffuse disease in which pathologic changes consist of an inflammatory and degenerative process occurring predominantly in the small vessels (2-4). However, except for Raynaud's phenomenon, peripheral vascular diseases as clinical manifestations of SLE have received relatively little attention in the literature. There have been only isolated reports of gangrene of the extremities (5-8), ischemic ulcers (9-14), thrombophlebitis, and erythermalgia (15) occurring in SLE. The purpose of this paper is to review the peripheral vascular manifestations of SLE and to illustrate them


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