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Hemodynamic and Metabolic Studies on Shock Associated with Bacteremia: Observations on 16 Patients

VASANT N. UDHOJI, M.B., B.S.; and MAX HARRY WEIL, M.D., PH.D., F.A.C.P.
Ann Intern Med. 1965;62(5):966-978. doi:10.7326/0003-4819-62-5-966
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Acute hypotension and clinical features of shock may be presenting features in patients who have bacteremia caused by endotoxin-producing gram-negative bacteria. Our present understanding of the hemodynamic abnormalities in this type of shock is incomplete, and current concepts of pathophysiology are largely based on animal studies. The extrapolation of findings in experimental animals to the understanding of bacterial shock in human patients is difficult because of species differences, the artificiality of an experimental model that employs single injections of endotoxins, and the special circumstances of infection and underlying disease in human patients (1, 2).

Two years ago, we (3) reported

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