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ACTH Producing Matastases from Carcinoma of the Esophagus

Ann Intern Med. 1965;62(5):1017-1022. doi:10.7326/0003-4819-62-5-1017
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The association of Cushing's syndrome with "nonendocrine" tumors has been discussed in several recent reviews (1-3). The most frequent sites of primary tumor have been the lungs, thymus, or pancreas. Meador and associates (4) in 1962 demonstrated adrenocorticotropin-like activity in five patients with hypokalemia, hypercorticism, and bilateral adrenal hyperplasia associated with neoplasms not of pituitary or adrenal origin. Adrenocorticotropic hormone (ACTH)-like material was present in the primary tumor, in metastatic tissue, and in the plasma of each patient. Liddle and associates (5) subsequently demonstrated active ACTH-like material in the primary and metastatic tumor of 13 patients. They suggested a change


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