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The Etiology of Mitral Regurgitation: The Marfan Syndrome.

Charles F. Wooley, M.D.; Don M. Hosier, M.D.; William Molnar, M.D.; and Joseph M. Ryan, M.D., F.A.C.P.
Ann Intern Med. 1965;62(5):1070. doi:10.7326/0003-4819-62-5-1070_1
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The occurrence of varying cardiovascular abnormalities in patients with the Marfan syndrome, particularly aortic dilatation, regurgitation, and dissection, is well-recognized. However, mitral valve deformities as part of the Marfan syndrome have been recognized and reported infrequently.

The association of the Marfan syndrome, mitral regurgitation due to intrinsic abnormalities of the mitral valve complex, and dilated sinuses of Valsalva with large aortic cusps (without aortic regurgitation) is the subject of this report.

Four female patients with evidence of the Marfan syndrome (one infant, one child, and two adults) were studied. All had auscultatory and either catheterization or cineradiographic evidence or both


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