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Abstracts |

Studies of the Clinical Spectrum and Pathogenesis of Tropical Sprue.

Theodore M. Bayless, M.D.; and Munsey S. Wheby
Ann Intern Med. 1965;62(5):1081-1082. doi:10.7326/0003-4819-62-5-1081_4
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The "enigma of tropical sprue" (Manson-Bahr) continues to interest physicians. Primary dietary folic acid deficiency does not seem to be the cause of tropical sprue, but folic acid therapy results in both absorptive and hematologic improvement. Antibiotics are also effective therapy, but bacteriologic studies of jejunal fluid are unrevealing. Symptoms may start after residents of the tropics move to temperate zones.

This is the report of studies of (1) clinical manifestations and histologic alterations in the small intestine in 125 patients with tropical sprue; (2) bone marrow morphology in early, nonanemic patients; and (3) rapid effects of folic acid and


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