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Does Treponema Pallidum Persist After Treatment of Late Syphilis?

Anne Roof Yobs, M.D.; Sidney Olansky, M.D., F.A.C.P.; Donald H. Rockwell, M.D.; and John W. Clark Jr., B.S.
Ann Intern Med. 1965;62(5):1088-1089. doi:10.7326/0003-4819-62-5-1088_4
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Collart, Borel and Durel (1962, 1964) reported the persistence of Treponema pallidum in lymph nodes of 12 patients previously treated for seroreactive, usually manifest, late syphilis with large amounts of heavy metals and penicillin. Similar findings were reported in the study of rabbits treated with massive amounts of penicillin 2 years after infection with T. pallidum.

Because of the implication that penicillin is ineffective in late syphilis, a similar study was undertaken using T. pallidum immobilizing test (TPI)-reactive male volunteers whose previous treatment for syphilis could be documented. A surgically excised inguinal lymph node from each of 45 volunteers was


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