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Effect of Dose of Polyvalent Influenza Vaccine on Antibody Response in an Aged Population.

Samuel Saslaw, M.D., Ph.D., F.A.C.P.; and Harold N. Carlisle, Ph.D.
Ann Intern Med. 1965;62(5):1089. doi:10.7326/0003-4819-62-5-1089_1
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Elderly people represent a high risk group in influenza virus infections and yearly vaccination with 1.0 ml of polyvalent vaccine is recommended. Studies in 1960 with 772 elderly persons (mean age, 63.8 years) showed that 1.0 ml of polyvalent vaccine subcutaneously was superior to 0.1 ml intracutaneously when given as the first injection but not as booster 3 months later. Follow-up studies in 1963 of 237 members of this group (mean age, 66.4 years) were conducted comparing H-I antibody response to 11 strains of influenza virus after 1.0, 0.5, 0.25 ml of polyvalent vaccine subcutaneously and 0.1 ml intracutaneously. Antibody


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