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Abstracts |

Gram-negative Bacteremia in Dogs.

Burton A. Waisbren, M.D., F.A.C.P.; James W. Hainer, B.S.; Irving Lutsky, V.M.D.; and Theofilos Tsaqaris, M.D.
Ann Intern Med. 1965;62(5):1089. doi:10.7326/0003-4819-62-5-1089_2
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This investigation was undertaken to see if the injection of living gram-negative bacilli into dogs would give a picture more similar to gram-negative shock in humans than that seen after the injection of endotoxin into dogs. The first dog injected intravenously with living Escherichia coli proved to be resistant not only to large numbers of living organisms but also to a concentration of 10 mg/kg of endotoxin (that is, five times the lethal dose). Forty-eight of the next 50 dogs injected with living E. coli died in spite of the therapy of chloramphenicol, hydrocortisone, and the combination of chloramphenicol and


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