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Five Year Study of Simultaneous Antimetabolites and Alkylating Agents in the Chemotherapy of Advanced Breast Carcinoma.

Ezra M. Greenspan, M.D., F.A.C.P.
Ann Intern Med. 1965;62(5):1093. doi:10.7326/0003-4819-62-5-1093_1
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Ninety-eight patients with multifocal metastatic breast carcinoma were treated with simultaneous combinations of thio-triethylenephosphoramide (TEPA) plus methotrexate (TP + MTX), cyclophosphamide (Cytoxan®) (Cyt) plus 5 fluorouracil (FU), TP + MTX + FU, or Cyt + MTX + FU. Maintenance alkylating agent (Alk) therapy (TP or Cyt) and intermittent courses of metabolic inhibitors (MTX or 5 FU) were given for 1 to 2 years. Central nervous system (CNS), hepatic, and diffuse preterminal disseminated metastases were also treated with moderate prednisone dosage. Hematostimulative supportive therapy included aqueous crystalline testosterone to masculinization, and monthly vitamin B12.

In a first group of 40 androgen-resistant


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