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A Genetic, Clinical, and Psychological Study of Nine Sets of Monozygotic Twins, Discordant for Rheumatoid Arthritis.

Ralph F. Jacox, M.D., F.A.C.P.; Sanford Meyerowitz, M.D.; and D. William Hess, M.D.
Ann Intern Med. 1965;62(5):1096. doi:10.7326/0003-4819-62-5-1096_2
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Nine sets of monozygotic twins, identified by extensive blood typing and in three instances by a successful skin graft acceptance, have been studied. One individual of each set of twins has rheumatoid arthritis by clinical criteria. In six sets, antinuclear antibodies were also present in the affected member. None of these serological abnormalities existed in the unaffected twins. One affected twin has had rheumatoid arthritis for 24 years, whereas the normal twin has had no disease. These data, along with recent American Indian population studies, provide evidence that rheumatoid arthritis is not an inheritable disease.

Psychological data have been collected


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