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Cushing's Syndrome Due to Islet Cell Carcinoma of the Pancreas: Report of Two Cases: One with Elevated 5-hydroxyindole Acetic Acid and Complicated by Aspergillosis

BETTYE A. SAYLE, M.D.; PATRICIA A. LANG, M.D.; WILLIAM O. GREEN JR., M.D.; WILLIAM C. BOSWORTH, M.D.; and RAYMOND GREGORY, M.D.
Ann Intern Med. 1965;63(1):58-68. doi:10.7326/0003-4819-63-1-58
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Adrenocortical hyperplasia associated with nonpituitary neoplasms is a well-known clinical entity. Twelve cases due to carcinoma of the pancreas have been reported (1-12). Of these, there were five adenocarcinomas (1-5), six islet cell carcinomas (6-11), and one ductal carcinoma (12). The purpose of this report is to record two additional cases of Cushing's syndrome with islet cell carcinoma of the pancreas and some unusual associated findings.

CASE REPORTS: CASE 1J. P., a 62-year-old white female, was admitted to The John Sealy Hospital on October 24, 1958, with a diagnosis of Cushing's syndrome. In May, 1958, she had the onset

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