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Albright's Hereditary Osteodystrophy: The Effect of Treatment During Adolescence

Ann Intern Med. 1965;63(1):140-146. doi:10.7326/0003-4819-63-1-140
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Albright's hereditary osteodystrophy is a rare genetic disorder that, in its fully developed form, has previously been called pseudohypoparathyroidism. Parathormone resistant hypocalcemia and hyperphosphatemia are present. These patients may exhibit short stature, round face, mental retardation, hypocalcemic tetany (refractory to correction with parathyroid extract), and osseous abnormalities. A less common variant, usually termed pseudo-pseudohypoparathyroidism, which has the same anatomic abnormalities as those found in patients having pseudohypoparathyroidism but with normal serum calcium and phosphorus levels has also been described. Pseudo-pseudohypoparathyroidism is considered to be an incompletely expressed form of pseudohypoparathyroidism. The effect of treatment during adolescence has not been reported


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