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A Long-term View of Bacterial Endocarditis: 337 Cases 1924 to 1963

S. RABINOVICH, M.D.; J. EVANS, M.D.; I. M. SMITH, M.D., F.A.C.P., M.R.C.P. (GLAS.); and L. E. JANUARY, M.D., F.A.C.P.
Ann Intern Med. 1965;63(2):185-198. doi:10.7326/0003-4819-63-2-185
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With the advent of chemotherapy and antibiotics, the perspective of bacterial endocarditis changed radically. A disease that was uniformly fatal became a serious disease that could be cured. With potentially effective treatment an early and accurate diagnosis improved the prognosis. Many aspects of the clinical features and the type of bacteria responsible for the endocarditis are not found in the same proportions as before the era of antibiotics. At the University of Iowa Hospitals there has been a continuing interest in bacterial endocarditis since 1924 (1-5); therefore, we have available at one institution an unusually large number of cases for

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